Can vitamin B6 produce toxicity?

Vitamin B6 (pyridoxine) causes neuropathy at intakes of 1000 mg per day or more, which is about 800 times the daily intake from foods. There have also been occasional reports of toxicity at intakes of 100-300 mg per day.

What is pyridoxine toxicity?

Pyridoxine toxicity is a recognised cause of sensory neuropathy. Schaumburg et al described sensory neuropathy after pyridoxine misuse in 1983. 1. It can occur with chronic use of pyridoxine supplementation over several years, and also with acute over‐dosage with parenteral pyridoxine.

Which vitamin B causes toxicity?

The RDA for vitamin B6 (pyridoxine) is 1.3 mg for adults between 19 and 50 years. . An acute toxic dose has not been established but it is known that vitamin B6 may cause neurotoxicity at a dose of 300 to 500 mg per day over time. In 2015, 189 toxic exposures were reported for Vitamin B6.

What causes vitamin B6 deficiency?

Vitamin B6 deficiency is usually caused by pyridoxine-inactivating drugs (eg, isoniazid), protein-energy undernutrition, malabsorption, alcoholism, or excessive loss. Deficiency can cause peripheral neuropathy, seborrheic dermatitis, glossitis, and cheilosis, and, in adults, depression, confusion, and seizures.

What is the toxicity of vitamin C?

For adults, the recommended daily amount for vitamin C is 65 to 90 milligrams (mg) a day, and the upper limit is 2,000 mg a day. Although too much dietary vitamin C is unlikely to be harmful, megadoses of vitamin C supplements might cause: Diarrhea. Nausea.

What is vitamin B6 deficiency?

Who is at risk for vitamin B6 deficiency?

Vitamin B6 deficiency is more common in people with liver, kidney, digestive or autoimmune diseases, as well as smokers, obese people, alcoholics and pregnant women ( 2 , 3 , 4 ).

What is the significance of a pyridoxine vitamin B6 deficiency?

Vitamin B6 deficiency causes peripheral neuropathy and a pellagra-like syndrome, with seborrheic dermatitis, glossitis, and cheilosis, and, in adults, can cause depression, confusion, electroencephalogram abnormalities, and seizures. Rarely, deficiency or dependency causes seizures in infants.

What is pyridoxine deficiency and toxicity?

Pyridoxine deficiency and toxicity … Pyridoxine, or vitamin B6, deficiency and toxicity can involve changes predominantly in hematologic, dermatologic, cardiovascular, gastrointestinal, and neurologic systems.

Does pyridoxine interact with vitamin B6?

Several drugs have interactions with vitamin B6 and can interfere with their levels. These medications typically lower the level of pyridoxine and leave to vitamin B6 deficiency and not toxicity. Isoniazid, cycloserine, penicillamine, and L-dopa all form complexes with vitamin B6, limiting its bioavailability.

How much pyridoxine is safe to take a day?

Daily dietary intake will not provide enough pyridoxine to cause toxicity. The daily dietary intake of vitamin B6 is approximately 1.9 mg/day in the United States.[2]  Additionally, typical pyridoxine doses used for co-treatment with isoniazid are 10 to 25 mg/day.

Does pyridoxine hydrochloride (HCl) cause anemia?

There have been select cases of B6-related anemia in which taking the inactive pyridoxine hydrochloride (HCl) form of the vitamin didn’t help. However, supplementing with the body’s most active form of B6, called pyridoxal 5’-phosphate (PLP), resolved the anemia ( 16 ).