What type of protein is transferrin?
glycoproteins
Transferrins are glycoproteins found in vertebrates which bind to and consequently mediate the transport of Iron (Fe) through blood plasma. They are produced in the liver and contain binding sites for two Fe3+ ions. Human transferrin is encoded by the TF gene and produced as a 76 kDa glycoprotein.
What is transferrin in chemistry?
Transferrin is a blood plasma glycoprotein that helps with the uptake, possession, and transportation of iron(III) throughout the circulatory system of various vertebrates. Hemoglobin is an oxygen-transport metalloprotein founded in red blood cells.
Is transferrin a type of globulin?
Transferrin (TFN) is a β-globulin responsible for transportation and deposition of serum iron. This protein has a half-life of 8–10 days, and the liver is the main (although not the exclusive) site of its synthesis [36].
Is transferrin the same as ferritin?
Ferritin is stored in the body’s cells until it’s time to make more red blood cells. The body will signal the cells to release ferritin. The ferritin then binds to another substance called transferrin. Transferrin is a protein that combines with ferritin to transport it to where new red blood cells are made.
What does transferrin mean in a blood test?
A transferrin test is carried out to directly measure the level of iron in the blood and also the body’s ability to transport iron in the blood. The transferrin blood test is ordered if the doctor suspects abnormalities of iron levels in your body. The tests help diagnose chronic iron overload or deficiency.
Is transferrin produced by the liver?
Your liver makes transferrin. When your body’s stores of iron run low, your liver produces more transferrin to get more iron into your blood. Iron plays many important roles in your body, including helping your red blood cells carry oxygen to the cells in your body.
Is transferrin an antioxidant?
One of the most important mechanisms of antioxidant defense is thus the sequestration of iron in a redox-inactive form by transferrin. The antioxidant capacity of apotransferrin to inhibit lipid peroxidation by iron-binding decreased in a concentration-dependent manner from 89% at > or = 2 mg/ml to 42% at 0.5 mg/ml.
What is the difference between ferritin and iron blood test?
Ferritin isn’t the same thing as iron in your body. Instead, ferritin is a protein that stores iron, releasing it when your body needs it. Ferritin usually lives in your body’s cells, with very little actually circulating in your blood.
What happens when your transferrin is high?
The normal range for transferrin is 204 to 360 mg/dl. If you have a higher amount, you may have iron-deficiency anemia. If you have a lower level, you may have another problem, such as liver disease and hemolytic anemia. Transferrin may also be measured using a value called total iron-binding capacity (TIBC).