What drugs interact with bisphosphonates?

Drug Interactions Magnesium-containing drugs like Milk of Magnesia (magnesium hydroxide) or Maalox (magnesium with aluminum) Diuretics or “water pills” such as Lasix (furosemide) or Edecrin (ethacrynic acid) Antbiotics like Amphosin and Fungizone (amphotericin B), amikacin, or gentamicin.

What drug class is Aredia?

Pamidronate belongs to a class of drugs known as bisphosphonates. It works by slowing the release of calcium from bones to lower blood calcium levels, reducing the risk of broken bones (fractures) and reducing bone pain.

Is Aredia a bisphosphonate?

Aredia is a bisphosphonate. Bisphosphonate medications are used to slow down the osteoclast’s effects on the bone. In doing this it can be useful in slowing down or preventing the complications (bone pain, fractures, or high calcium levels) of the bone breakdown.

How often is Aredia given?

The recommended dose of Aredia in patients with osteolytic bone metastases is 90 mg administered over a 2-hour infusion given every 3-4 weeks.

Who should avoid bisphosphonates?

Clinicians should avoid oral bisphosphonates in patients who are at a higher risk of these gastrointestinal adverse effects, including those who are not able to sit upright for at least 30 minutes after taking the bisphosphonate, and patients with esophageal disorders such as achalasia, esophageal stricture, Barrett’s …

Can you take calcium with bisphosphonates?

Therefore, patients receiving bisphosphonates should take supplemental calcium and vitamin D. However, calcium and other mineral (eg, magnesium, iron) supplements can interfere with the absorption of bisphosphonates, and they should not be taken for at least one hour after taking oral bisphosphonates.

What is Aredia used to treat?

Pamidronate is used to treat high blood calcium levels and certain bone problems (bone metastases/lesions) that may occur with some types of cancer. It is also used to treat a certain type of bone disease (Paget’s disease) that causes abnormal and weak bones.

Is Aredia used for osteoporosis?

This can slow bone loss and may help prevent bone fractures. Aredia is used to treat Paget’s disease of bone. This medicine is also used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy).

What is the J code for Aredia?

J2430 Pamidronate disodium /30 mg – HCPCS Procedure & Supply Codes.

Why do bisphosphonates cause osteonecrosis?

The mechanism by which BPs cause osteonecrosis is not proven but is probably due to a combination of decreased bone remodelling, poor wound healing, and an antiangiogenic effect leading to ischaemic changes and subsequent necrosis in response to a local traumatic insult.

Why is calcium given with bisphosphonates?

Patients with osteoporosis who adhere to drug therapy experience a significantly lower fracture rate. Therefore, there is a need to improve correct intake of bisphosphonates together with calcium supplementation, which may enhance adherence.

What are the side effects of Aredia?

In rare cases, this medicine may cause bone loss ( osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Aredia, the more likely you are to develop this condition.

This medicine is also used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy). Aredia is also used to treat bone damage caused by certain types of cancer such as breast cancer or bone marrow cancer. This medicine does not treat the cancer itself.

How many mg of Aredia are in a vial?

Aredia, pamidronate disodium (APD), is a bisphosphonate available in 30-mg or 90-mg vials for intravenous administration. Each 30-mg and 90-mg vial contains, respectively, 30 mg and 90 mg of sterile, lyophilized pamidronate disodium and 470 mg and 375 mg of mannitol, USP.

How long should an infusion of Aredia be given?

Longer infusions (i.e., > 2 hours) may reduce the risk for renal toxicity, particularly in patients with preexisting renal insufficiency. The recommended dose of Aredia in severe hypercalcemia (corrected serum calcium* > 13.5 mg/dL) is 90 mg given as a SINGLE-DOSE, intravenous infusion over 2 to 24 hours.