What does high mannose binding lectin mean?
A role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE.
How is mannose binding lectin deficiency treated?
Treatment for individuals with recurrent infections and MBL deficiency may include antibiotics to treat bacterial infections and regular vaccinations. Prophylactic antibiotics may be indicated in some cases.
What does mannose binding lectin recognize?
MBL recognizes specific carbohydrates such as d-mannose, l-fucose and N-acetylglucosamine that are represented on the surface of a wide variety of infectious agents (Figure 1b) [1]. Pathogens targeted by MBL include certain Gram-positive and Gram-negative bacteria, yeast, parasites and viruses [9].
Where does mannose binding lectin come from?
It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. Expression and function in other organs were also suggested.
What is normal range for mannose binding lectin?
Normal serum levels of MBL range from 800 to 1000 ng/ml in healthy Caucasians, however, wide variations can occur due to point mutations in codons 52, 54 and 57 of exon 1 and/or in the promotor region of the MBL gene [3].
Where does mannose-binding lectin come from?
What is MBL in immunology?
Mannose-binding lectin (MBL) is a pattern recognition molecule of the innate immune system. It belongs to the collectin family of proteins in which lectin (carbohydrate-recognition) domains are found in association with collagenous structures.
Is the lectin pathway regulated?
Regulation of the lectin pathway overlaps with that of the classical pathway; however, MASP-3, Map44 and Map19, which are homologous to MASP-1 and 2, can bind to MBL, ficolins and collectins and inhibit activation of the pathway.