How is benzocaine synthesized?

The classic, optimal way of benzocaine synthesis is the reduction of the nitro group of the ethyl ester of 4-nitrobenzoic acid to benzocaine by hydrogen, which generates directly in the reaction medium by the reaction of iron filings with dilute acids [24–26]. …

Which antiarrhythmic drug is a derivative of para aminobenzoic acid?

Procaine, the 2-diethylaminoethyl ester of 4-aminobenzoic acid (2.1. 1), better known as novocaine, is synthesized in two ways. The first way consists of the direct reaction of the 4-aminobenzoic acid ethyl ester with 2-diethylaminoethanol in the presence of sodium ethoxide.

What is benzocaine made of?

Benzocaine is a chemical compound derived from para-aminobenzoic acid and ethanol. It is a white, odorless, crystalline powder. It acts on neuronal membranes and blocks nerve signals in the body. Its numbing effects are temporary.

Is benzocaine a base?

Benzocaine occurs in two forms: a crystalline salt (benzocaine HCl) that is soluble in water at 0.4 g/L, and a nonwater-soluble basic form that must be dissolved in ethyl alcohol at a concentration of 0.2 g/ml before it is sufficiently soluble in water to create a functional induction dose.

What is the biological relevance of 4 aminobenzoic acid?

4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group. It has a role as an Escherichia coli metabolite, a plant metabolite and an allergen.

What is para-aminobenzoic acid used for?

Para-aminobenzoic acid (PABA) is a compound found in milk, eggs, grains, and meat. It is best known as the active ingredient in sunscreen. PABA has been used to improve discoloration in skin and hair and to ease digestion.

What is the action of benzocaine?

It works by blocking nerve signals in your body. Benzocaine topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body.

Is Benzocaine a liquid?

Facts about benzocaine and prescription local anesthetics Benzocaine products are available as gels, sprays, ointments, solutions, and lozenges.

How do you synthesize P-aminobenzoic acid?

As shown in Scheme 1, in order to prepare p-aminobenzoic acid, toluene is first nitrated to synthesize ortho-nitrotoluene and para-nitrotoluene, which are separated, and then p- Nitrotoluene is oxidized to prepare p-nitrobenzoic acid, and the nitro group of p-nitrobenzoic acid is synthesized by reduction using an …

What is the chemical formula of para-aminobenzoic acid?

4-Aminobenzoic acid/Formula
p-Aminobenzoic acid, also known as 4-aminobenzoic acid or PABA, is an organic compound with molecular formula C7H7NO2. PABA is a white crystalline substance that is only slightly soluble in water. It consists of a benzene ring substituted with an amino group and a carboxylic acid.

What is vitamin b11 called?

Molecular Function. Vitamin B1. Thiamine. Thiamine plays a central role in the release of energy from carbohydrates. It is involved in RNA and DNA production, as well as nerve function.

How do you make p-aminobenzoic acid?

Step 1: Preparation of p-aminobenzoic acid. Place 15 g (0.09 mol) of p-nitrobenzoic acid in a 1-litre round-bottomed flask fitted with a reflux condenser. Introduce 35 g (0.295 mol) of powdered tin and 75 ml of concentrated hydrochloric acid. Heat the mixture gently until the reaction commences, and remove the flame.

What is the mechanism of action of benzocaine?

Benzocaine is an ester of paraaminobenzoic acid, lacking the terminal diethylamino group of procaine, with anesthetic activity. Benzocaine binds to the sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited,…

What is the CAS name for 2-aminobenzamide?

The Chemical Abstracts Service (CAS) name is 2-aminobenzamide (CAS Reg. No. 88-68-6). As a scavenger for acetaldehyde in polyethylene terephthalate (PET) beverage bottles.

What is the environmental impact of 2-aminobenzamide on the environment?

2-Aminobenzamide’s production and use as an azoic dye intermediate may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 2.6X10-5 mm Hg at 25 deg C indicates 2-aminobenzamide will exist in both the vapor and particulate phases in the atmosphere.