Can endometriosis raise CA 125?

Plasma concentrations of CA125 are markedly elevated in women with cystic ovarian endometriosis and/or deeply infiltrating endometriosis, but not, or only slightly, in the luteal phase of women with minimal or mild endometriosis.

Can endometriosis cause high CA19 9?

In conclusion, endometriosis is significantly associated with elevated serum CA125 and CA19-9 concentrations, and CA19-9 is increased further in the more advanced stages of disease. Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.

What is the highest CA 125 level?

While a CA 125 level over 35 may indicate cancer, it does not always mean the person has cancer….CA 125 Levels Chart.

CA 125 Levels (units/mL) Potential Cancer
0 – 35 (normal) Unlikely to have cancer. 99% of the time, it means no cancer.
>35 (high) Possible cancer. More tests will be needed for a diagnosis.

Why is CA 125 test done for endometriosis?

Cancer antigen 125 (CA-125) is a glycoprotein biomarker that is used in women with pelvic masses such as endometriosis and maybe is useful in practice of patients suspicious to endometriosis (3). It serves as an ovarian cancer biomarker, especially for monitoring of ovarian cancer therapy and early recurrences (4, 5).

What is the difference between endometrioma and endometriosis?

Endometriomas are cystic lesions that stem from the disease process of endometriosis. Endometriomas are most commonly found in the ovaries. They are filled with dark brown endometrial fluid and are sometimes referred to as “chocolate cysts.” The presence of endometriomas indicates a more severe stage of endometriosis.

Can an ovarian cyst cause high CA-125?

Elevated CA-125 (a protein in the blood that’s associated with ovarian cancer) is most often caused by common, ordinary or benign conditions such as uterine fibroids, ovarian cysts, endometriosis — or even just having your period.

What is the difference between CA-125 and CA 19-9?

The specificity of the CA 125 test, 83.3%, was slightly lower than the specificity of the CA 19-9 test. The main difference between the 2 tests was the low sensitivity of the CA 125 test, estimated to be 60.8%.

What is a bad CA-125 level?

The tumor marker Ca 125 is a prognostic factor. Levels around 100 U/l are indicative of a bad prognosis.

What cancers does CA-125 detect?

Cancer antigen 125 (CA125) is a protein found on most ovarian cancer cells that is secreted into the blood stream and can be measured….The CA125 blood levels can be increased in ovarian cancer and other cancers including:

  • uterine.
  • fallopian tube.
  • pancreatic.
  • breast.
  • colorectal.
  • lung.
  • stomach.

What are the benign causes of elevated ca 125 levels?


  • Liver disease
  • Menstruation
  • Pelvic inflammatory disease
  • Pregnancy
  • Uterine fibroids
  • When to worry about CA-125?

    Ca 125 is very non specific- it is not recommended to be done as a screening test. Only useful for somebody who has ovarian cancer and known to have related increased of ca 125 – to monitor response of teatment and as a follow up. If you’re worry about ovarian cancer-you need to see a gynecologist.

    What will a CA125 test Tell Me?

    The CA-125 test looks for certain proteins in your blood. Ovarian cancer can be the reason for these proteins, but other conditions can cause them to be in your blood as well. Your doctor may order a CA-125 test if you’re about to start treatment for ovarian cancer.