Which glial cells are affected in MS?
Expert opinion: Microglia, astrocytes, and oligodendrocytes are each promising targets for the disease-altering treatment of multiple sclerosis. Though challenging, the opportunities presented have great potential for CNS regeneration and further investigation of glial cells in therapy is warranted.
How does MS affect the autonomic nervous system?
Multiple sclerosis is an inflammatory disease leading to disseminated lesions of the central nervous system resulting in both somatomotor and autonomic disturbances. These involve the central centers of the autonomic nervous system, as well as the automatic control and pathway systems.
Can MS cause dysautonomia?
Although reports on the symptoms of autonomic dysfunction in patients with MS are increasing, the nature of the dysautonomia in MS remains unclear.
Which symptoms is characteristic of patients with multiple sclerosis?
Symptoms
- Numbness or weakness in one or more limbs that typically occurs on one side of your body at a time, or your legs and trunk.
- Electric-shock sensations that occur with certain neck movements, especially bending the neck forward (Lhermitte sign)
- Tremor, lack of coordination or unsteady gait.
What happens to the glia in MS?
In MS, reactive astrocytes both attract immune cells to a damaged nerve, and also surround and contain the active lesion. Astrocytes are involved in making the actual lesion scar, which prevents the damage spreading, but also prevents neural repair.
How does MS affect the body on a cellular level?
With MS, damaging immune-system cells (macrophages and other lymphocytes) are able to break through the BBB and enter the CNS, where they begin their attack on the myelin. This creates inflammation along the nerves where the myelin is being damaged. Areas of activity are known as lesions (or plaques).
Can MS affect vagus nerve?
Individuals with Multiple Sclerosis have a damaged vagus nerve which partially paralyses the stomach.
Can MS affect the sympathetic nervous system?
A lower than normal function of the sympathetic nervous system (SNS) has been identified early in the course of multiple sclerosis (MS) and has been shown to play a role in the pathology of the disease.
Does MS affect the vagus nerve?
Can MS make you pass out?
Some people with MS experience dizziness and the sensation of being lightheaded, woozy, weak, or faint.