What is the role of chromosome 11?
Chromosome 11 likely contains 1,300 to 1,400 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.
Can I get pregnant with a balanced translocation?
BALANCED TRANSLOCATION AND RECURRENT MISCARRIAGE Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.
What does t11 22 mean?
There are many different types of translocations, however the t(11;22) is known as a reciprocal translocation and is the most common recurring reciprocal translocation seen in humans. A reciprocal translocation means that there is a two way exchange of information between these two chromosomes.
Where is chromosome 11 in the body?
We have analyzed the human ONA sequences present in a human-mouse somatic cell hybrid line possessing a translocation involving human chromosomes 11 and X. These data indicate that the human insulin gene is located on the short arm of chromosome 11 in the region p13→pter.
What is chromosome 11 deletion syndrome?
Jacobsen syndrome is a condition caused by a loss of genetic material from chromosome 11. Because this deletion occurs at the end (terminus) of the long (q) arm of chromosome 11, Jacobsen syndrome is also known as 11q terminal deletion disorder.
Does balanced translocation cause birth defects?
This is because a person with a balanced translocation can make egg or sperm cells with too much of one chromosome and too little of the other. This can cause infertility, miscarriage or the birth of a child with intellectual disabilities and/or birth defects.
How common is balanced translocation?
Balanced chromosome translocations, in which sections of chromosomes change their geographical position on the chromosomal map without any loss or gain of important genetic material, are an important cause of recurrent miscarriages because they are common; one in 500 people carries a balanced translocation.
What is the 11/22 translocation?
Unique also has a general guide to Balanced Translocations The 11;22 translocation: the bottom bit of one chromosome 11 changes places with the bottom bit of one chromosome 22 3 Why has this happened? Balanced translocations happen naturally.
What is a balanced translocation?
It is called a balanced translocation when the breaks in the chromosomes do not pass through a gene and no material appears to be gained or lost. Someone with a balanced translocation is called a carrier . They usually have no health or developmental problems, although they may have difficulties when they want to have children.
What are the chances of translocation to the 11th chromosome?
First, any heterozygous translocation involving the relevant chromosome, be it 1 or 11, should cause the disease in 50% of carriers, as long as it separates the two loci.
Can a woman with a balanced translocation have a baby?
Most men and women with a balanced translocation are able to have children. It may take longer for a pregnancy to be established because a proportion of their sperm or eggs have unbalanced chromosomes and any embryos cannot survive. Miscarriage and pregnancy loss