Does Hemabate need to be refrigerated?
HEMABATE must be refrigerated at 2° to 8° C (36° to 46° F).
How long is Hemabate stable at room temperature?
The compounds were basically stable for 6 days in water and in saline, whether they were stored at 4 degrees C or at room temperature. However, only half of the dosage of misoprostol was recovered in the solution. Therefore, misoprostol dosage should be adjusted before clinical application.
How long does Hemabate last?
Dosage for Hemabate For abortion and other indications, an initial dose of 1 mL (250 mcg) is administered deep in the muscle. Subsequent doses of 250 mcg are administered at 1½ to 3½ hour intervals depending on uterine response.
Where do you give Hemabate?
An initial dose of 1 mL of HEMABATE Sterile Solution (containing the equivalent of 250 micrograms of carboprost) is to be administered deep in the muscle with a tuberculin syringe. Subsequent doses of 250 micrograms should be administered at 1½ to 3½ hour intervals depending on uterine response.
When is Hemabate used?
Hemabate (carboprost tromethamine) Sterile Solution is a form of prostaglandin (a hormone-like substance that occurs naturally in the body) used to treat severe bleeding after childbirth (postpartum). Hemabate is also used to produce an abortion by causing uterine contractions.
What is the most common side effect of Hemabate?
General. -Contractile effect on smooth muscle, nausea, vomiting, diarrhea, increased temperature and flushing are the most frequent adverse reactions observed. -Adverse effects of this drug are generally transient and reversible when therapy ends.
Is Hemabate used for abortion?
Hemabate is used to treat severe bleeding after childbirth (postpartum). Hemabate is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons.
How is Hemabate used?
What is Hemabate and how is it used? Hemabate (carboprost tromethamine) Sterile Solution is a form of prostaglandin (a hormone-like substance that occurs naturally in the body) used to treat severe bleeding after childbirth (postpartum). Hemabate is also used to produce an abortion by causing uterine contractions.
When should you not use Hemabate?
You should not receive Hemabate if you have active pelvic inflammatory disease, a breathing disorder, heart disease, liver disease, or kidney disease. This medicine in given in a hospital or clinic setting to quickly treat any serious side effects that occur.
What is Hemabate?
What class of drug is Hemabate?
Hemabate Overview Hemabate belongs to a group of medications called prostaglandins. These work by causing uterine contractions. Hemabate is available in an injectable form that is given directly into a muscle (IM) by a healthcare professional.
What is the purpose of Hemabate?
INDICATIONS AND USAGE. HEMABATE is indicated for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. Prior treatment should include the use of intravenously administered oxytocin, manipulative techniques such as uterine massage and, unless contraindicated,…
How do you administer Hemabate 250 mg?
An initial dose of 250 micrograms (1.0 ml) of Hemabate should be administered as a deep intramuscular injection. If necessary, further doses of 250 micrograms may be administered at intervals of approximately 1.5 hours.
Is Hemabate safe to take short term?
There is no evidence that short term administration of HEMABATE Sterile Solution can cause similar bone effects. In patients with a history of asthma, hypo- or hypertension, cardiovascular, renal, or hepatic disease, anemia, jaundice, diabetes, or epilepsy, HEMABATE should be used cautiously.
What are the ingredients in Hemabate sterile solution?
Each mL of Hemabate Sterile Solution contains carboprost tromethamine equivalent to 250 mcg of carboprost, 83 mcg tromethamine, 9 mg sodium chloride, and 9.45 mg benzyl alcohol added as preservative. When necessary, pH is adjusted with sodium hydroxide and/or hydrochloric acid.